Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis.

At the class level, the relative abundance of Bacteroidia showed an increasing trend in the berberine treatment group (BerL and BerH), while it showed a decreasing trend in the BerM group.

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Results showed that the relative abundances of beneficial bacteria showed a decreasing trend in the UC model, and the taurine conjugated bile acids increased from the liver tissue to the colon tissue.

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