On the other hand, overall levels of chromosomal copy number aberrations appeared to trend higher in lymphomas (mean gains + losses: 225.2 ± 173.7 Mb) as compared to healthy tissues (mean gains + losses: 87.3 ± 127.5 Mb; p = 0.06), irrespective of their STIL transgene status (Figs 4J and 5I ), although the difference did not quite reach statistical significance.
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STIL overexpression shortens lifespan and reduces tumor formation in mice.
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