Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy.

J Exp Clin Cancer Res · 2024 · PMC11545160 · PMID 39511626

Europe PMC DOI

hedged sentences

0.0150

closest p · 0.3× alpha

0.4720

boldest claim

The sentences

highly significantp = 0.015actually significant

6C), and again a highly significant difference was observed between patients below and above the cut-off (median OS (mOS): 1003 vs 173 days, p = 0.015, HR: 2.366 [95%CI:1.159–4.833], p = 0.018, Fig. 2 B, Supp.Fig. 6D).

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a slight trendp = 0.472not close (p > 0.1)

When using the median (120.61 pg/ml) to divide patients in the Aachen ICI cohort , only a slight trend towards a longer PFS could be shown in patients with values below the median ( p = 0.472, Supp.Fig. 6A), so that we calculated an absolute and relative ideal cut-off (ICO) to separate patients according to PFS (cut-off sCD27:63.98 pg/ml or 2.25 × median of controls).

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