3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma.

Indeed, permanent expression of LMP1 in the BJAB-tTA-LMP1 cell line induces significant down-regulation of telomere repeat binding factor 1 (TRF1), TRF2 and protection of telomere 1 (POT1) at both the transcriptional and translational level (the most impressive down-regulation (>60%) was observed in TRF2), resulting in a highly significant increase of multinucleated, LMP1+ RS-like cells ( p < 0.0001) on days 14 and 21 [ 67 ].

also in 132,142 other papers