Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data.

We further showed that the effect sizes of the associations between macronutrient intake and plasma FGF21 were somewhat attenuated but still highly significant when restricting to individuals with obesity (BMI ≥30) ( Supplementary table 3 ) and when restricting to individuals that had fasted for at least 6 h before given their blood sample ( Supplementary table 4 ).

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