In 2012, a GWAS of nsSag identified two significant loci, on chromosome 20 near BMP2 and on chromosome 7 within BBS9 , with the lead single‐nucleotide polymorphisms (SNPs) exhibiting highly significant odds ratios (4.38 and 4.17 in the meta‐analyses, respectively), compared to controls (Justice et al., 2012 ).
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Reassessing the association: Evaluation of a polyalanine deletion variant of RUNX2 in non-syndromic sagittal and metopic craniosynostosis.
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