Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

When QT intervals were corrected for heart rate, [ 27 ] as shown in Figure 5H , the difference between the control and the mGpTx1 treatment animals were also highly significant (n = 8, p < 0.001): QTc intervals were 0.07 ± 0.01 s and 0.12 ± 0.01 s, respectively; and T‐wave amplitude was significantly decreased after treatment with 0.3 mg kg −1 mGpTx1 (control: 0.20 ± 0.03 mV; mGpTx1: 0.09 ± 0.02 mV; n = 8, p = 0.0138).

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