highly significantp = .0118
Whilst prescriptions of HDOs were falling before September 2019 with a slope of −0.0719 ± 0.0282, they continued to fall afterwards at a significantly steeper rate than before with a new slope of −0.195 ± 0.0350 and this change in trend was highly significant (ANCOVA, F (1,22) = 7.529, p = .0118) ( Figure 4 , Supplement Figure 2(i) ).