The lipid metabolite 1-linoleoylglycerol (1-monolinolein) showed a notable I 2 of 21% and a pleiotropy p-value nearing significance (Egger intercept p-value = 0.0781), indicating potential pleiotropic effects influencing its association with EMs.
Other notable findings include glucose (carbohydrate) with an I 2 of 11% and no significant pleiotropy (Egger intercept p-value = 0.3449), and 1-oleoylglycerophosphocholine (lipid) with I 2 = 7% and a marginally non-significant pleiotropy p-value (Egger intercept p-value = 0.1477).
A high level of heterogeneity was noted for leucine (amino acid) with an I 2 of 9% and a borderline significant pleiotropy (Egger intercept p-value = 0.1682), suggesting the need for cautious interpretation.