External damp environment aggravates diarrhea in spleen deficiency and dampness syndrome in mice: involvement of small intestinal contents microbiota, energy metabolism, gastrointestinal and fluid functions.

The villus height/crypt depth ratio also differed significantly among the groups: the ZL group presented a significant difference compared with the ZC group ( p <0.01), whereas the ZLZ group presented an extremely significant difference from the ZLZS group ( p <0.001).

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Compared to the ZC group, the relative abundances of Ligilactobacillus and Dwaynesavagella in the ZLZ group exhibited a decreasing trend, whereas the relative abundances of Mammaliicoccus and Streptococcus increased.

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Figure 5D shows an increasing trend in serum cyclic guanosine monophosphate (cGMP) across all groups, although this trend was not statistically significant.

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