Age-related increase of CD38 directs osteoclastogenic potential of monocytic myeloid-derived suppressor cells through mitochondrial dysfunction in male mice.

The result indicates a positive trend between the Cd38‐ expressing myeloid cells and an increase in the expression of genes in the bone resorption GO term (Figure 5f ). 3.6 Effect of 78c on M‐ MDSCs osteoclastogenic potential The primary enzyme that breaks down NAD + in the bone marrow is CD38.

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