Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects.

While reproducing the decrease in average epigenetic age, this clock demonstrates no statistically significant difference between the days 0 and 15 of in vitro reprogramming in one dataset (Ohnuki et al., 2014 ) (Figure 5c ), and marginal significance between days 0 and 17 in another dataset (Gill et al., 2022 ) (Figure 5d ).

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