Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts.

Statistical differences were shown as significant * p < 0.05, very significant ** p < 0.01, and highly significant *** p < 0.001. 3 Results and Discussion 3.1 Functionalized PEGylated Mesoporous Silica Nanoparticles Retard Cancer Metastasis According to our previous study, 25 nm diameter PEGylated mesoporous silica nanoparticles (MSNs) with quaternary amine modification of TA molecular (denoted as MSN-PEG/TA) were synthesized. 29 , 34 The TEM images and particle size distribution histograms for MSN-PEG/TA 25 are depicted in Figure 1 a, revealing a well-defined porous structure.

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