Noradrenergic alpha-2a receptor stimulation enhances prediction error signaling and updating of attention sets in anterior cingulate cortex and striatum.

The overall firing rate correlations with trial outcomes increased after outcome onset and was stronger in the Guanfacine than vehicle condition in dlPFC, striatum and with a statistical trend in the ACC (Fig. 3A ; permutation test, dlPFC: p < 0.05 during 0.5–0.6s; striatum: p < 0.05 during 0.05–0.3s; ACC: p < 0.075 during 0.4–0.45s).

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