MRI of the brain and orbits may help identify patients with MS or those who are at risk for the same.[ 8 ] Yet, it is important to carefully interpret MRI studies since there may be significant overlap in the radiologic features of ON associated with MS, MOGAD, and NMOSD.[ 11 ] To optimize MRI sensitivity, incorporating coronal short tau inversion or fat-suppressed T2 images, along with post-gadolinium fat-suppressed T1 images of the optic nerve with thin section slices (<2 mm up to the chiasm) has been recommended,[ 40 ] with newer imaging modalities on the horizon.
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