Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy.

12 15 The frequent amplification of PD-L1 and PD-L2 in EBVaGC suggests that immune evasion may be significant in EBVaGC oncogenesis.

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Examining PTGS2 gene expression, there was highly significant upregulation in EBV(−) compared with EBV+ GCs, consistent with findings from our current study ( figure 6A ).

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