Succession of the multi-site microbiome along pancreatic ductal adenocarcinoma tumorigenesis.

In the saliva, microbes in C1 including Fusobacterium mortiferum , Lactiplantibacillus plantarum , and Loigolactobacillus coryniformis presented a decreasing trend from CP to stage IV PDAC patients ( Figure 2C and Supplementary Table S4 ).

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Microbes in C3 and C4, which involve a group of well-known periodontitis pathogens such as Porphyromonas gingivalis , Treponema denticola , Porphyromonas endodontalis , and Filifactor alocis presented an increasing trend from CP to stage IV PDAC patients.

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