The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats.

Results The action of Hesperidin on VPA-produced cell cycle arrest The VPA group had a considerably significantly larger number of p21-stained cells than the vehicle group ( P < 0.05, Fig. 1 a-b and e) Conversely, receiving HSD significantly reduced the p21-stained cells in the VPA + HSD group in contrast to the VPA group ( P < 0.05, Fig. 1 d and e).

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