The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I.

BMC Biochem · 2002 · PMC115839 · PMID 12052259

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may be significantno p-value reported

Therefore there may be significant differences in the mechanisms of type IA topoisomerases from different organisms with respect to requirement of Zn(II) binding for relaxation activity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.