Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability.

Investigating this association in a cohort of 227 medulloblastomas, we found that loss of chr3p was highly significant when searching for genomic regions tightly linked with CT (Fig. 5c , two-sided Fisher exact test, p < 10 −5 and two-sided Chi-square test, p < 10 −8 , respectively).

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