A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5.

Nat Immunol · 2024 · PMC11588656 · PMID 39424985

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0.0050

closest p · 0.1× alpha

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highly significantP = 0.005actually significant

Analysis of publicly available proteomics data from a cohort of ETV6-RUNX1 + and high hyperploidy (HeH + ) B-ALL cases 29 found a highly significant correlation between Pax5 and SIRT7 protein levels in these individuals ( P = 0.005; Fig. 6f ).

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