Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses.

Genet Epidemiol · 2024 · PMC11588973 · PMID 38472646

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hedged sentences

0.0700

closest p · 1.4× alpha

0.0800

boldest claim

The sentences

marginally significantp = 0.07so close (0.05 < p ≤ 0.1)

When the two PRSs were conditioned on each other (Model 3), the association with a woman's PRS remained unchanged, and the association with her sister's PRS attenuated 71% ( p = 10 −16 ) to be at best marginally significant (OPERA = 1.08, 95% CI: 0.99, 1.17; p = 0.07).

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marginally statistically significantp = 0.08so close (0.05 < p ≤ 0.1)

This is further supported by the ICE FALCON analyses which found that there was a marginally statistically significant ( p = 0.08) change in a woman's own PRS association after conditioning on her sister's PRS, and the sister's PRS association was marginally statistically significant ( p = 0.07) in Model 3.

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