highly significantp ≤ 0.001
marginally significantp ≤ 0.07
We considered the following levels of significance for p -values: (1) highly significant ( p ≤ 0.001), (2) significant ( p < 0.05), (3) marginally significant or trend-level significant (0.05 ≤ p ≤ 0.07), and (4) not significant.