Circadian Alterations in Brain Metabolism Linked to Cognitive Deficits During Hepatic Ischemia-Reperfusion Injury Using [¹H-¹³C]-NMR Metabolomics.

There was a marginally significant interaction between time and HIRI on Lac 3 (F = 4.338, p = 0.051, Supplementary Table S4 ), with mean comparisons indicating a decrease in Lac 3 enrichment in the HIRI group compared to the control at ZT0, but a significant increase at ZT12 post-HIRI ( Supplementary Figure S1A ).

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