Highly Calibrated Relationship Between Bleomycin Concentrations and Facets of the Active Phase Fibrosis in Classical Mouse Bleomycin Model.

Bleomycin Less than 1 U/kg Induces Dose-Dependent Pulmonary Inflammation The BALF analysis for inflammation reveals a dose-dependent 3–14-fold increase in total leukocyte count, which was markedly significant ( p < 0.01) in mice dosed at 0.05–0.5 U/kg bleomycin ( Figure 1 C and Supplementary Figure S5 ).

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