Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice.

dPmax increased significantly, but RI showed only an increasing trend or remained unchanged.

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FVC showed a decreasing trend in the single instillation model and a significant reduction in the five-time instillation model, resulting in a maintained FEV100/FVC ratio similar to other studies on pulmonary fibrosis [ 31 , 33 ].

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