highly significantp < 0.001
This effect of PEG was not significant for HPMC-based ODFs and CMC-based ODFs ( p > 0.05), but was highly significant for the other ODFs ( p < 0.001) and may be due to its higher solubility-enhancing effect. 38 Study limitations Although different polymers and plasticizers were used in the study, their amounts were kept constant.