Adult Onset Foveomacular Vitelliform Dystrophy Shows Genetic Overlap With Age-Related Macular Degeneration.

The score summarizing variants unrelated to complement or lipid metabolism was higher in AMD (mean ± SD = 0.03 ± 0.02) compared with AFVD (mean ± SD = −0.15 ± 0.05, P = 0.004), and showed a borderline significance level for being lower in AFVD compared with controls (mean ± SD = −0.02 ± 0.05, P = 0.05; Fig. 2 ).

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This score showed a borderline significant difference between patients with AFVD (mean ± SD = 0.95 ± 0.12) and controls ( P = 0.05).

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There was a nonsignificant trend for association of the HTRA1 risk allele genotypes with AFVD, but this was not identified at the allele count.

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