Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms.

JCI Insight · 2024 · PMC11601571 · PMID 39325545

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fell just short of significanceno p-value reported

While no single QTL passed the significance threshold, the lead QTL on proximal chromosome (Chr) 4 ( Eaecc1 ; LOD score = 6.79) fell just short of significance ( Supplemental Figure 10 , A and B, and Table 2 ).

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fell short of significanceno p-value reported

Analysis of classic-EAE incidence yielded a top QTL on Chr5 that fell short of significance ( Eaecc2; LOD score = 6.64; Supplemental Figure 10 , C and D, and Table 2 ).

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highly significantno p-value reported

A 2-way ANOVA of the effect of strain and sex on CDS (analyzed separately for classic-EAE, AR-EAE, or combined disease) revealed a highly significant effect of strain (as expected), no overall effect of sex, and a significant strain by sex interaction in the case of classic-CDS ( Figure 3, A–C ).

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