Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin.

Further, we explore the impact of inhibiting HFD-mediated EV secretion and the modulation of oncogenic proteins in adipose and uterine tissues, our study employed a small molecule inhibitor targeting EV regulatory pathway proteins (STAT3 and TMEM205) [ 18 , 25 , 26 ], along with Metformin to inhibit EV secretion, the administration of HO-3867 and Metformin showed a notable trend towards reduced body weights (Supplementary Fig. 9 ).

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