Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis.

Glucose production is increased with MASLD severity, IR, and lipolysis In the EPoS-flux group, tracer-measured HGP was significantly higher in subjects with MASH compared to MASL, with an increasing trend from MASL to MASH-F0/F1 to MASH-F2 to MASH-F3/F4 ( Figure 1 A, Kruskal-Wallis p value = 0.01).

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