KL‑6, ET‑1 and S100A9 levels in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea.

Exp Ther Med · 2025 · PMC11609610 · PMID 39624594

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closest p · 1.2× alpha

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borderline significanceP=0.06so close (0.05 < p ≤ 0.1)

In the IPF-OSA group S100A9 levels were also correlated with indices of OSA severity ( Table SIII ), including TST90 (r=0.34, P=0.03) and with a borderline significance after adjustments for obesity, smoking and GAP index (β=0.015, P=0.06), ODI (r=0.36, P=0.023) which persisted after adjustments for obesity, smoking and GAP index (β=0.013, P=0.02), and nocturnal mean SaO 2 (r=-0.32, P=0.04), but this correlation disappeared after adjustments for obesity, smoking and GAP index.

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marginally statistically significantP=0.06so close (0.05 < p ≤ 0.1)

Regarding ET-1, increased serum levels were detected in the IPF-OSA group, compared with IPF patients without OSA, although this result was marginally statistically significant (P=0.06) ( Table III ; Fig. 3 ).

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