Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics.

However, within ST regions characterized by elevated target density, the cell survival probability did not necessarily exhibit a decreasing trend; in some instances, particularly for PSMA and GRPR, it even displayed a slight increase.

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In both the 177 Lu- and 225 Ac-PSMA targeting RPT graphs, there is a slight trend towards increased cell survival at the very tail of the distributions for PC1 and PC2 (Figure 5 A, Figure S4 ) .

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