Role of DNA methylation transferase in urinary system diseases: From basic to clinical perspectives (Review).

Int J Mol Med · 2025 · PMC11611324 · PMID 39575487

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For example, antitumour drugs such as methylation inhibitors 5-azacytidine and 5-aza-2′-deoxycytidine can specifically inhibit the methylation of certain genes that suppress tumour growth and metastasis and regulate cell cycle, playing a corresponding role in curbing tumour proliferation with fewer side effects; these drugs are likely to be significant in cancer treatment in the future ( 170 , 178 - 181 ).

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