Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity.

After the intervention with covariates included (BCAA supplementation and running), HCRs had lower CO 2 production ( p = 0.048) and higher O 2 consumption during darkness, which was close to being significant ( p = 0.079, Table 2 ).

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Thus, a low serine level may be significant factor in both diabetic and prediabetic conditions, though the potential mechanisms are not yet known.

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