Global, Regional, and National Trends in Liver Disease-Related Mortality Across 112 Countries From 1990 to 2021, With Projections to 2050: Comprehensive Analysis of the WHO Mortality Database.

However, Oceania exhibited a decreasing trend (Oceania: 107.20 deaths per 1,000,000 people) ( Table 1 ).

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The LOESS smoothed curves of liver disease-related mortality rates were overwhelmingly highest in Africa (116.98 deaths per 1,000,000 people [95% CI, −21.65, 255.62] in 1990 to 374.28 deaths per 1,000,000 people [247.00, 501.56] in 2021), while there was an increasing trend in Asia, America, and Europe (Asia: 136.58 [95% CI, 113.41, 159.74] in 1990 to 158.16 deaths per 1,000,000 people [95% CI, 133.68, 182.65] in 2021; America: 104.84 [82.53, 127.14] in 1990 and 171.78 [141.53, 202.04] in 2021; Europe: 106.36 [87.59, 125.12] in 1990 and 167.88 [147.15, 188.61] in 2021).

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