Immunoproteasome Activation Expands the MHC Class I Immunopeptidome, Unmasks Neoantigens, and Enhances T-cell Anti-Myeloma Activity.

Biomedical implications of immunoproteasome activators may be significant to overcome deficiencies in immunoproteasome activity as seen in proteasome-associated autoinflammatory syndromes, as well as modulate antitumor immune responses, autoimmune and neurodegenerative diseases, and aging.

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