PD-L1 thresholds predict efficacy of immune checkpoint inhibition in first-line treatment of advanced gastroesophageal adenocarcinoma. A systematic review and meta-analysis of seven phase III randomized trials.

ESMO Open · 2024 · PMC11613432 · PMID 39541621

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

of borderline significanceP = 0.07so close (0.05 < p ≤ 0.1)

PD-1 blockade was effective in the CPS <10 population ( P value for pooled OS HR, PFS HR and response OR are all 0.01), while in the CPS <5 population the effect was of borderline significance for OS ( P = 0.07) and significant for PFS and ORR ( P = 0.02 and 0.03, respectively).

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