Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites.

Fluorescence imaging of the cells 96 hours post-transfection showed highly significant increases in fluorescence intensity for six out of eight reporters when the active DENV2 protease was expressed ( Fig 3D ), with only reporters comprising the SQQKTDWIP and PEKQRTPQDN sites failing to show an increase in fluorescence.

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