PI3K-dependent reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes.

While HK2-deficient mice exhibited normal frequencies of CD19 + B cells in the spleen, peritoneal wash, mesenteric lymph nodes, and Peyer’s patch, a small but significant reduction in B lineage cells within the bone marrow was noted ( Figures 3 E and S4 A).

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