Efficacy of melatonin for prolonged disorders of consciousness: a double-blind, randomized clinical trial.

In our findings, following the melatonin intervention, there was a notable trend towards an increase in the relative spectral density of high-frequency oscillations at alpha frequencies when compared to the placebo group (Fig. 3 A, F group*time = 4.330, P = 0.037; F group = 3.52, P = 0.060; F time-mel = 3.04, P = 0.081).

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