Global, regional, and national burden of dengue infection in children and adolescents: an analysis of the Global Burden of Disease Study 2021.

Existing studies have reported the global burden of dengue based on data from the Global Burden of Disease Study (GBD) and have identified an increasing trend in global incidence and dengue deaths over the past decades.

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From 1990 to 2021, of the 17 GBD regions with recorded dengue incidence, 14 showed an increasing trend in ASIR, the highest increasing trend was in High-income North America (EAPC = 6.28%, 95% CI, 4.87%–7.69%), and only two regions showed a decreasing trend in ASIR (Eastern Sub-Saharan Africa [EAPC = −9.90%, 95% CI, −12.23% to −7.58%] and Southern Sub-Saharan Africa [EAPC = −1.85%, 95% CI, −2.76% to −0.94%]) ( Table 1 and Fig. 3 A).

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