highly significantP-values < 0.001
2 A), including CD4, CASP8, HSP90AA1, BAX, CALR, and PDIA3, all exhibiting highly significant differences (P-values < 0.001); ENTPD1, TLR4, IL10, and IL17RA showed notable differences (P-values < 0.01); while IL6, IL1B, NLRP3, and HMGB1 also demonstrated differences (P-values < 0.05).