The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model.

By calculating a DNA methylation score (Methylation score) for each single cell and displaying it on a UMAP plot ( Figure 4A ), we found that cells in PDAC samples generally have higher DNA methylation scores, showing highly significant differences compared to ADJ samples (p = 2.4e-11, Figure 4B ).

also in 132,142 other papers