Despite the limited number of differentially expressed genes, there was highly significant overlap between the two cell types (48% of DE genes in GMPs, 38% of DE genes in BMDMs), including Xaf1 , Anxa6, Pttg1 , H2aw and Nlrp1b (Supplementary Fig. 2d, e ).
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Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3<sup>tm1Flv</sup> mice.
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