Fungal microbiome in gut of systemic lupus erythematosus (SLE)-prone mice (pristane and FCGRIIb deficiency), a possible impact of fungi in lupus.

In established SLE mice, alpha diversity (variety of microbial species) showed an increasing trend in FcγRIIb-/- (KO) mice, as indicated by OTUs and Chao richness ( Fig 1 ), suggesting an immune response impact on gut fungi.

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Thus, bacterial-fungal interactions during active lupus may be significant is possible, and exploring fungi and gut translocation of beta-glucan may yield new biomarkers or novel treatment strategies for SLE, including antifungal treatments or probiotics.

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