A complex mechanism translating variation of a simple genetic architecture into alternative life histories.

Proc Natl Acad Sci U S A · 2024 · PMC11621623 · PMID 39560647

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a notable trendno p-value reported

DEGs with VGLL3 promoters or enhancers showed a notable trend with the majority having higher expression in vgll3 EE individuals (5/5 VGLL3 promoters, 17/23 VGLL3 enhancers), suggesting that transcriptional upregulation associated with the VGLL3 E protein was stronger compared to the VGLL3 L protein.

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an increasing trendno p-value reported

Our expression data showed that seasonal expression of ncoa1 was dependent on vgll3 genotype; a declining expression in vgll3 LL genotype suggested investment on adiposity, while an increasing trend in vgll3 EE genotypes was suggestive of utilization of fat reserves to promote pubertal initiation.

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