Association of pre-existing conditions with major driver mutations and PD-L1 expression in NSCLC.

BMJ Open Respir Res · 2024 · PMC11624786 · PMID 39632102

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

nearing significancep=0.059so close (0.05 < p ≤ 0.1)

Predictors for L858R mutations included female gender (OR 1.319, 95% CI 1.057 to 1.650, p=0.015), age 50 and older (OR 1.859, 95% CI 1.447 to 2.407, p<0.001), never-smoking status (OR 0.589, 95% CI 0.454 to 0.763, p<0.001), adenocarcinoma histology (OR 3.419, 95% CI 2.403 to 5.012, p<0.001), a family history of other cancers (OR 2.089, 95% CI 1.029 to 4.135, p=0.037) and hypertension (OR 1.252, 95% CI 1.001 to 1.562, p=0.048), with early-stage tumours nearing significance (p=0.059).

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borderline significanceno p-value reported

Additionally, blood type AB (compared with type O, 8.0% vs 6.4%, p=0.058) and a family history of other cancers (1.8% vs 1.1%, p=0.055) showed borderline significance.

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