However, there was an increasing trend in reactive astrogliosis in the injured cortices of CHI mice receiving iNSCs pretreated with Akt-specific LACs (data not shown), which is consistent with previous studies, suggesting that Akt activation is a potential driver of astroglial differentiation (Lee et al., 2010; Gao et al., 2021).
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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury.
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