Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis.

However, NK cells consistently showed marginal significance (defined as nominal p < 0.05) for heritability enrichment in cell-type-specific open chromatin regions across two independent GWAS and in the cell-type-specific expression analysis where NK cells were compared with T cell subsets using a curated list of genome-wide significant loci for AS.

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